Advanced Sampling for Molecular Simulation is Coming of Age

Angiogenesis is coming of age.

Angiogenesis, the formation of blood vessels from preexisting vessels, occurs during embryonic and adult life. Although vascular endothelial cells in the normal adult organism have a very low turnover, they resume proliferation in diseases that are associated with neovascularization, such as solid tumor growth, wound healing, and retinopathy. A host of recent publications has indicated that the...

Molecular diagnostics of lymphoma: coming of age.

Molecular diagnostics of ADPKD coming of age.

E ver since the first autosomal dominant polycystic kidney disease (ADPKD) gene was localized to a chromosomal interval (PKD1: 16p13.3) in 1985, brave souls have been performing molecular-based diagnostics (1). The enthusiasm was tempered by the discovery of a second gene (PKD2: 4q21) and suggestions of a third, with the realization that reliable linkage-based diagnostics required families larg...

The society is coming of age.

In 1986 it was 20 years since the European Society for Clinical Respiratory Physiology (SEPCR) was founded. At that time the Society met jointly with the SEP in Paris and it did not seem appropriate to celebrate the anniversary then. However, on the occasion of the Society's 21st congress and at the start of the life of its new journal it is appropriate and opportune to review the past, the pre...

4Pi-Confocal Microscopy Is Coming of Age

Fluorescence microscopy is one of the most favored imaging techniques in biological research: It allows non-invasive imaging of sub-cellular structures inside of live cells, specifically labeled by biological markers such as the green fluorescent protein (GFP). The confocal laser-scanning microscope or its multiphoton versions stand out by their ability to provide 3D-images. However, like any o...